Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis affecting the venous or arterial vascular systems, and/or obstetrical morbidity along with the persistent presence of antiphospholipid antibodies (aPL), including lupus anticoagulant, anticardiolipin antibody and anti-beta-2-glycoprotein-I (β2GPI) (1). The gene discussed is APOH; the disease is deep vein thrombosis.