Consistent with a metastasis-suppressive role for UBR7 and its lower levels in metastatic tumors, UBR7-WT overexpressing MDA-MB-231 cells, but not UBR7-CM-overexpressing MDA-MB-231 cells, were unable to seed to the lung upon intravenous injection, whereas control cells formed overt lung metastases (Fig. 4h). The gene discussed is UBR7; the disease is metastatic neoplasm.