Previous studies in postmortem brain revealed decreased MBP mRNA and protein levels in schizophrenia patients.12–15 However, Mbp expression was shown to be modulated by antipsychotic treatment in mouse16 and in an independent study, it was found to be upregulated in the blood of antipsychotic-naive schizophrenia patients.17 The gene discussed is MBP; the disease is schizophrenia.