CYP1B1 and pulmonary arterial hypertension: The increased CYP1B1 expression in VAT and the subsequent increase in urinary 16αOHE1 levels observed in male ob/ob and HFD mice may directly contribute to the pulmonary hypertension phenotype observed in these animals, given the beneficial effects of CYP1B1 inhibition on pulmonary hypertension observed in ob/ob mice.