SHANK1 and Anxiety: In addition, we found genes involved in synaptic plasticity: Adcy8, whose deficiency led to stress-induced anxiety [52] implying a role in long-term potentiation and synaptic plasticity for fear related memory [38], Cacna1c (Cav1.2 subunit of L-type calcium channel), which mediates long-term synaptic plasticity through calcium signaling, Klhl1, the actin binding protein modulating calcium current [53] and neurite outgrowth [54], and Shank1, the anchoring protein playing a role in glutamatergic synaptic plasticity [55].