However, it is worth noting that signet-ring cell carcinoma, another subtype of adenocarcinoma characterized by abundant intracellular mucin such that their nucleus is displaced aside, has shared molecular features with mucinous colorectal adenocarcinoma, including the presence of MSI-H, CpG island methylator phenotype-high (CIMP-H), and frequent BRAF mutations [26]. This evidence concerns the gene MUC5AC and colorectal mucinous adenocarcinoma.