SP1 and atherosclerosis: C-159T base at − 159 lies 49 bp adjacent to an experimentally detected binding site for transcription factor Sp1 at − 110 and 1 bp adjacent to a putative Ap2 site at − 158, it was considered to be an important CD14-activating mediator of inflammatory responses that may result in atherosclerosis, coronary heart disease (CAD), thrombus formation and myocardial infarction (MI) [54].