In addition, as described in detail previously TAR DNA-binding protein 43 (TDP-43)-immunoreactive deposition can be detected in neurodegenerative tauopathy, including Alzheimer disease [2, 16], Pick disease [4], corticobasal degeneration [19], progressive supranuclear palsy [20], and argyrophilic grain disease [5]. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.