Diseases with secondary TDP-43 pathology include AD and hippocampal sclerosis [2, 16], Guam parkinsonism–dementia complex [8], Pick disease [4], corticobasal degeneration [19], progressive supranuclear palsy [20], argyrophilic grain disease [5], and Lewy body disease [15]. This evidence concerns the gene TARDBP and progressive supranuclear palsy.