Notably, Slc6a3, a gene encoding a sodium-dependent dopamine transporter and associated with anxiety disorder in autism spectrum disorder [56], is upregulated (by 4 fold) in the neocortex of TDP-43 cKO mice but only at the age of 3 months (Additional file 3: Table S2) [7, 9, 23, 28, 32, 39, 41, 50, 51, 66, 69, 90]. The gene discussed is TARDBP; the disease is anxiety disorder.