TARDBP and amyotrophic lateral sclerosis: TDP-43 in the diseased cells of the patients’ brains of FTLD-TDP or spinal cords of ALS-TDP is characterized with abnormal ubiquitination, hyperphosphorylation, and enhanced cleavage to generate the 25 kDa and 35 kDa C-terminal fragments (TDP-25 and TDP-35) [4, 54].