FZD8 and neoplasm: In the current study, we observed two genes of this pathway upregulated in the P breast, FZD8 (frizzled family receptor 8) which is a transmembrane receptor transducing WNT signals, and EAF2 (ELL-associated factor 2), which is important for early embryonic development and critical for adult tissue homeostasis and prevention against tumor initiation [37, 38].