Fourthly, overexpression of wild-type SOX11 in low invasive HNSCC cells (UM2 and UMSCC6) induced the expression of SDCCAG8 whereas over-expression of mutant SOX11 in highly invasive HNSCC cells (UM1 and UMSCC5) abolished the expression of SDCCAG8. The gene discussed is SOX11; the disease is head and neck squamous cell carcinoma.