As shown in Fig. 4C and D, both Sdccag8 mRNA and protein expression levels were significantly up-regulated in highly invasive UM1 and UMSCC5 cells when compared to low invasive UM2 and UMSCC6 cells, suggesting that the expression levels of Sox11 and Sdccag8 are highly correlated in HNSCC cells. The gene discussed is SDCCAG8; the disease is head and neck squamous cell carcinoma.