To further verify if SOX11 regulates the expression of SDCCAG8 in HNSCC cells, luciferase reporter assays were performed on UM2 and UMSCC6 cells using Sdccag8 gene promoter reporter plasmid, Sox11 plasmid (Sox11F) and a mutant lacking the transactivation domain (Sox11FΔTAD). Here, SOX11 is linked to head and neck squamous cell carcinoma.