As presented in Fig. 5C, overexpression of wild-type SOX11 induced the expression of SDCCAG8 in low invasive HNSCC cells (UM2 and UMSCC6) whereas over-expression of mutant SOX11 (Sox11FΔTAD) abolished the expression of SDCCAG8 in highly invasive HNSCC cells (UM1 and UMSCC5). This evidence concerns the gene SDCCAG8 and head and neck squamous cell carcinoma.