Although there has been clear evidence of SDCCAG8 in regulating cellular functions (e.g., cell cycle, mitotic G2-G2/M phases, recruitment of centrosome proteins, etc.)[31, 43, 50], the underlying mechanisms of SDCCAG8 in cancers, particularly in HNSCC, are largely unknown. The gene discussed is SDCCAG8; the disease is head and neck squamous cell carcinoma.