The glycosaminoglycan chains of heparan sulfate proteoglycan (HSPG) can be degraded by heparanase (HPSE), generating oligosaccharides that intensify the effects of growth factors, cytokines, and angiogenic factors, triggering cell proliferation, cell differentiation, and angiogenesis, which favor tumor development [2–5]. This evidence concerns the gene HPSE and neoplasm.