Moreover, the role of HPSE2 in carcinogenesis is still the subject of investigation, and it has been suggested that HPSE2 is involved in the inhibition of HPSE activity, regulates selected genes that promote normal differentiation, endoplasmic reticulum stress, tumor fibrosis, apoptosis and is a tumor suppressor [40]. The gene discussed is HPSE; the disease is neoplasm.