Through PPI network construction, a series of hub genes/proteins has been observed to form a local network, including JUN, DCN, THBS1, HLA-DRA, EDN1, TIMP3, TGFB2, OAS3, OASL, OAS1, PDGFB, MMP1, EGR1, SDC4 and SERPINE1, of which most DEGs have been reported to associate with cancer development. This evidence concerns the gene EDN1 and cancer.