We treated PRMT5-silenced pancreatic cancer cells with the proteasome inhibitor MG132, and the western blotting results demonstrated that MG132 could attenuate the decrease in the cMyc protein level, further confirming the hypothesis that PRMT5 could regulate cMyc at the posttranslational level (Fig. 4c). This evidence concerns the gene PRMT5 and familial pancreatic carcinoma.