As for those negatively associated with PCDH17, only 3 of the 8 genes have previously been associated with carcinogenesis: miR-1269 was shown to mediate tumor metastasis by targeting HOXD10 in colorectal cancer [52]; the two other microRNAs (miR-508 and miR-135a-1) were mainly implicated in drug resistance. The gene discussed is HOXD10; the disease is colorectal cancer.