DKK1 and cancer: Among them were negative regulators of epithelial-mesenchymal transition (EMT)—SLIT2, ID4, and CDH1—all three genes were known to be regulated by methylation- and EZH2-mediated repression in cancers, and the Wnt antagonists, such as DKK1, WNT5A, and SOX17. One of the most differentially expressed genes was SPARCL1, whose repression has been reported as a negative prognostic indicator in a number of cancers [36, 37].