Our study shows that mice podocyte injury has been observed in AKI, that extensive podocyte fusion occurs in podocytes, and that expression levels of podocyte functional proteins including nephrin, CD2AP, and synaptopodin decrease while expression of TRPC6 increases, gradually aggravating proteinuria and subsequently hindering renal function, The pathology showed an increase in glomerular mesangial proliferation, glomerulosclerosis score, tubulointerstitial score, and the rising levels of glomerular, renal tubules, and interstitial collagen, eventually presenting chronic renal fibrosis. The gene discussed is SYNPO; the disease is acute kidney injury.