Similarly, bevacizumab, a VEGF inhibitor, manifested impressive values (PFS ranging from 5.3 months to 9.0 months, OS ranging from 5.9 to 13.7 months, and disease control rate [DCR] ranging from 51.1 to 76.9%) in the treatment of advanced HCC [12, 13]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.