Furthermore, 83 protein coding genes were solely downregulated in the TS vs. NS contrast, including immune response related genes Wnt1 inducible signaling pathway protein 1 (WISP1), V-set pre-B cell surrogate light chain 3 (VPREB3), C-X-C motif chemokine ligand 12 (CXCL12), and some B cell activation genes CD79B molecule (CD79B), switching B cell complex subunit (SWAP70), and cholinergic receptor nicotinic alpha 7 subunit (CHRNA7), which implied host adaptive immunity deficiency in the tumorous individuals. This evidence concerns the gene CXCL12 and hyperinsulinemic hypoglycemia, familial, 4.