Preeclampsia may arise due to an imbalance of angiogenic and antiangiogenic factors (such as soluble fms-like tyrosine kinase Flt-1 [sFlt-1] and PlGF, an important pathogenic factor in the development of preeclampsia), which may affect endometrial vascular development or function during pregnancy. The gene discussed is PGF; the disease is preeclampsia.