However, after correcting by age, length of infection, co-infection with hepatitis viruses and transmission route, variables that presented significant differences between INR and IR groups (Table 1), the multivariate logistic analysis showed that CCR2 rs1799864 AG genotype was significantly and independently associated to INR status (OR: 1.80 [1.04–3.11]; p = 0.036) and CXCL12 rs1801157 TT genotype showed a clear trend (OR: 2.47 [0.96–6.13]; p = 0.063) (Table 3). The gene discussed is CXCL12; the disease is coinfection.