While mRNA of the inflammatory cytokines Il-6 and Il1-β was not affected by CpG-C treatment (p = 0.9690 and p = 0.6772, respectively), Tnf and Inf-γ, which are known to synergistically induce apoptosis in tumor cells [54], were increased by approximately 2- and 7-fold, respectively (p = 0.0163 and p = 0.0374, respectively; Fig 8D). This evidence concerns the gene IL6 and neoplasm.