For instance, mutations in the mitochondrial aspartyl‐tRNA synthetase, DARS2 (MIM 610956), can lead to leukoencephalopathy (Scheper et al., 2007; van Berge et al., 2013), while dysfunctional leucyl‐tRNA synthetase, LARS2 (MIM 604544), has been linked to several pathogenic conditions including infertility and hearing loss (Pierce et al., 2013; Riley et al., 2016). This evidence concerns the gene DARS2 and Leukoencephalopathy.