Mutations in the mitochondrial tryptophanyl‐tRNA synthetase, WARS2 (MIM 604733), have been linked to developmental delay, intellectual disability, microcephaly, seizures, and brain atrophy (Burke et al., 2018; Musante et al., 2017; Theisen et al., 2017; Vantroys et al., 2018; Wortmann et al., 2017), but also with aggressive behavior (Musante et al., 2017) hepatopathy (Vantroys et al.,2018), or early onset Parkinsonism (Burke et al., 2018). Here, WARS2 is linked to Global developmental delay.