In addition, we noticed an aberrant overexpression of hypoxia‐inducible factor 1α (HIF1α) in many different cancers and HK‐2 is one of its downstream transcriptional targets.35, 36 In this study, we also found that a combination of PD and 2‐DG inhibited the protein expression of HIFIα in 4T1 and MCF‐7 cells (Figure 5A,B). The gene discussed is HIF1A; the disease is cancer.