FBN1 and Marfan syndrome: FBN1 mutation can lead to contractile dysfunction of smooth muscle cells (SMCs) with consequent reduced tensile strength of aortic tissue.2 Aortic complications such as aortic dilatation and dissection are the main cause of morbidity and mortality in patients with MFS.3 Although considerable progress has been made over the past decades in the treatment of MFS‐induced cardiovascular injury, including medical and surgical interventions, efficacy has been limited due to the unclear molecular aetiologies.