CYP3A4 and acute myeloid leukemia: We previously showed that most CYPs, including CYP3A4, as well as CDA were all highly expressed in BMSCs, but not AML and MM cells.10 To model the BM niche in AML patients, HL‐60, Kasumi‐1 or OCI‐AML3 cells were co‐cultured with human BMSCs for 72 hours and the expression of CYP3A4 and CDA in stroma cells was assessed by RT‐qPCR.