CDA and acute myeloid leukemia: We found that both AML cells, as well as inflammatory cytokines that are elevated during active disease, decrease CYP3A4 and CDA gene expression level in BMSCs similar to the effects of inflammatory cytokines on liver CYP3A4 expression.18 In addition, pretreatment of BMSCs with cytarabine induced AML drug resistance to etoposide.