EGFR and breast cancer: In addition, we explored the substitution of the phenyl ring of 4-anilino or 4-aryloxy moieties with, halogen, hydrogen bond donor (such as amino group), hydrogen bond acceptor (nitro, methoxy groups) or hydrogen bond donor/acceptor (sulphonylamino group) to substantiate the effect of such variations on the dual EGFR and VEGFR-2 inhibitory activity as well as their anticancer activity against MCF-7 breast cancer cell line.