Intriguingly, liver‐specific ROCK1‐deficient mice (L‐ROCK1−/−), but not control mice, showed a decrease in bodyweight concomitant with decreasing lipid accumulation in epididymal and mesenteric fat, increased energy expenditure, and higher locomotor activity after being fed a HFD, resulting in the prevention of diet‐induced obesity. Here, ROCK1 is linked to Obesity.