Briefly, they included CLL patients who (1) had deletion 17p or TP53 mutation with treatment indication, (2) were refractory to (or had early < 12 months relapse) purine analog-based therapy, and (3) had relapse < 24 months after purine analog combinations or autologous stem cell transplantation [2]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.