MAPT and progressive supranuclear palsy: Based on the regional distribution of MAO-B in the human brain, the areas with the highest concentrations (i.e. basal ganglia and thalami) do not overlap with the areas where tau pathology is primarily located in the AD brain but do overlap with those in non-AD tauopathies, such as corticobasal degeneration or progressive supranuclear palsy [38].