At least some of these mutants develop cataracts later in life (e.g. mutation in Cryba2, encoding βA2-crystallin; Puk et al. 2011a) or in homozygotes [(e.g. mutation in Lim2, encoding the lens intrinsic membrane protein 2; Puk et al. 2011b, or a mutation in Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2); Kunze et al. 2015; Fig. 3]. The gene discussed is LIM2; the disease is cataract.