In short, the candidate causal genes that were associated with both heart rate increase and recovery were also associated with resting heart rate (CCDC141, RGS6, RNF220, SCN10A, and SYT10), heart rate variability (CCDC141, RGS6, RNF220, and SYT10), blood pressure (CCDC141 and PAX2), atrial fibrillation (CAV2 and SCN10A), coronary artery disease (CAV2 and SCN10A), and ECG traits including the PR interval (CAV2 and SCN10A), QRS duration, and the Brugada syndrome (both SN10A). The gene discussed is RNF220; the disease is coronary artery disorder.