Up to 3% of patients with cancer experience hypercalcemia, with the majority of these patients having an advanced cancer diagnosis.106, 107 The increased calcium levels are typically due to increased parathyroid hormone–related protein (PTHrP) levels secreted by the tumor.108 PTHrP increases the bone‐resorbing activity of osteoclasts resulting in the hypercalcemia found in these patients. The gene discussed is PTHLH; the disease is Hypercalcemia.