As a consequence, TGF‐β, VEGF, IGF‐1, and other bone morphogenetic proteins are released into the bone microenvironment.139 In addition, tumor cells secrete cytokine such as IL‐6, IL‐8, and MCP‐1 that impact osteoclast differentiation.140 Exercise may be interrupting a number of the aforementioned pathways to reduce the metastatic burden in bone. The gene discussed is TGFB1; the disease is neoplasm.