Further, BMSC from Gfi1‐knockout mice or Gfi1 knockdown in murine OB precursors (pre‐OBs) before MM exposure significantly protected the cells from MM suppression with improved response to OB differentiation signals.16, 38 Importantly, knockdown of Gfi1 after MM exposure of murine pre‐OB or in patient‐derived MM‐BMSCs could reverse the OB suppression and enhanced response to OB differentiation signals. This evidence concerns the gene GFI1 and Miyoshi myopathy.