Inhibition of EZH2 reduced adipogenic differentiation of aged BMSCs and rescued their capacity for osteogenic differentiation.80 Jing and colleagues81 reported that elevated EZH2 expression in BMSCs correlated with increased H3K27me3 levels on the Wnt1, Wnt6, and Wnt10a promoters and resulted in their commitment to adipocyte differentiation with osteoporosis. This evidence concerns the gene EZH2 and osteoporosis.