A number of factors are thought to have a role in attracting tumor cells to the bone microenvironment, including the CXCL12/CXCR4 signaling axis.29 The chemoattractant CXCL12 (C‐X‐C motif chemokine ligand 12) is expressed on osteoblasts, and endothelial and bone marrow stromal cells, including mesenchymal stem/stromal cells (MSCs). Here, CXCL12 is linked to neoplasm.