Dysregulation of EBI2 expression has been demonstrated in EBV infection (68, 69, 73, 74, 76), melanoma metastasis, lymphoblastic leukemia, glioblastoma, bone cancer metastasis, systemic lupus erythematous, chronic rhino sinusitis with nasal polyps, Type 1 Diabetes (69), and CFS/ME (90) (see below). This evidence concerns the gene GPR183 and glioblastoma.