In addition, their diagnostic ability was also evaluated, and it appeared that IBSP, MMP9, MMP13, TNFAIP6, CD200, DHRS3, ASS1, RIPK4, and VIM may be considered as specific prognostic markers for bone metastasis to identify primary breast cancers that have potential to metastasize to bone tissue. The gene discussed is RIPK4; the disease is breast carcinoma.