ESR1 and Familial prostate cancer: Since ESR1 enjoyed the highest centrality among all naringenin-mediated proteins as proved previously, and because three overlapping proteins (PIK3CA, AKT1, MAPK1) associated with ESR1 were found to be connected to prostate cancer pathway as well, the genomic alteration of these four protein genes (ESR1, PIK3CA, AKT1, MAPK1) were checked in prostate cancer using cBioPortal.