Moreover, it is noted that NF-κB plays a fundamental role in the expression of proinflammatory molecules such as cytokines, chemokine, and adhesion molecules [53] and several studies demonstrated that it is highly involved in metabolic disorders and atherosclerosis [54, 55], thus evaluating the effect of carotenoids treatment on NF-κB nuclear translocation. The gene discussed is NFKB1; the disease is metabolic disease.