We found that TRIM52 expression was significantly up-regulated in 67.5% CRC tissues (54/80) compared to matched normal colonic mucosa (Fig. 1a) Western blotting analysis on 3 normal colonic mucosa specimens (C1–C3), 3 CRC specimens from up-regulated group and 3 CRC specimens from down-regulated group (L1–L3) validated the IHC results (Fig. 1b). The gene discussed is TRIM52; the disease is colorectal carcinoma.