For instance, S100A8 and S100A9 form a complex called calprotectin that aggravates psoriasis by regulating expression of the C3 complement factor, while hBD-2 promotes chemotaxis of various leukocytes in a C-C chemokine receptor (CCR) 2- and CCR6-dependent manner [26, 27]. This evidence concerns the gene C3 and psoriasis.