At 48 hours post-infection, the concentrations of total protein in S1PR1 ECKO mouse BALF were significantly increased compared with those in control mouse BALF (P = 0.024) (Fig. 2E), while the abundance of cytokine/chemokine was markedly upregulated in S1PR1 ECKO mouse BALF (Fig. 2F). The gene discussed is S1PR1; the disease is infection.