Moreover, mutations and/or deletions of 13 genes, namely, Strc, Chrna10 (cholinergic receptor, nicotinic, alpha polypeptide 10), Chrna9 (cholinergic receptor, nicotinic, alpha polypeptide 9), Ocm, Myo15 (myosin XV), Gfi1 (growth factor independent 1), Lhx3 (LIM homeobox protein 3), Barhl1 (BarH-like 1 (Drosophila)), Pjvk (pejvakin), Tomt (transmembrane O-methyltransferase), Pou4f3 (POU domain, class 4, transcription factor 3), Tmc1 (transmembrane channel-like gene family 1), and Grxcr2 (glutaredoxin, cysteine rich 2), cause hearing loss in humans and mice (Fig. 8b)26–28,38–50. The gene discussed is GFI1; the disease is hearing loss disorder.