Moreover, the expression levels of the other nine deafness-related genes (Myo15, Gfi1, Lhx3, Barhl1, Pjvk, Tomt, Pou4f3, Tmc1, and Grxcr2) were downregulated more than 2-fold in DT-treated Prestin-hDTR mice. The gene discussed is PJVK; the disease is deafness.