The TP53 mutation status had predictive significance when the TP53 mutations were categorised into (i) a group with LOF mutations and common hotspots (R273, R248, R175) that was compared with the survival of patients bearing cancers (ii) with the TP53 wild-type tumours or (iii) other, unclassified TP53 defects. Here, TP53 is linked to neoplasm.