Furthermore, we compared the expression levels of FBXW2 and β-catenin in the tumors with (51 cases) and without (39 cases) lymph-node metastasis, and found that the staining intensity of FBXW2 was significantly reduced in the tumors with lymph-node metastasis as compared to those without lymph-node metastasis, while the staining intensity of β-catenin was just opposite, which were statistically significant (Fig. 7c). Here, FBXW2 is linked to metastatic malignant neoplasm in the lymph nodes.