It is well established that the downstream signaling events involving the Wnt/β-catenin cascade occur through T-cell factor (TCF)-4 transcription factor proteins38,39, and different TCF4 isoforms generated by alternative splicing events activated different downstream target genes in hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC)40–42. The gene discussed is TCF4; the disease is hereditary clear cell renal cell carcinoma.