CDH1 and cyst: In addition, although adherens junction formation has been shown to depend on protein localization via the Par complex to establish an apical membrane domain in columnar epithelia (Müller and Wieschaus, 1996; Harris and Tepass, 2008; Baum and Georgiou, 2011), the death of spermatocytes after loss of Par complex function in cyst cells did not appear to result from destabilization of adherens junctions between cyst cells, as knockdown of E-cadherin in cyst cells did not result in spermatocyte death.