ASB2 and Familial prostate cancer: The cell migration-critical gene netrin 1 (NTN1), cellular adhesion molecule neuregulin 1 (NRG1), and the putative tumor suppressor sushi repeat-containing protein X-linked (SRPX) exhibit downregulation in prostate cancer as compared to normal prostate or benign prostate hyperplasia tissue [30–33], and evidence for association between the expression of ubiquitin ligase ASB2 and PCa progression is established in the literature [34, 35].