However, the other target genes possessed probes either within the peaks identified through our methylation sequencing strategy (ETNK2, MEIS2, NRG1, NUDT10) or closer to these DMSs than those for ASB2 (at distances of 328 bp, 160 bp, or 22 bp for ASB2, NTN1, or SRPX, respectively), and examination of methylation in matched tumor and normal samples from an independent series indicated concordant and increased 5mC within the ASB2 TET2-KO DMS. Here, NRG1 is linked to neoplasm.