Correlation of TET2-target genes with clinicopathological characteristics of PCa revealed a panel of seven promising candidates—ASB2, ETNK2, MEIS2, NRG1, NTN1, NUDT10, and SRPX—exhibiting discriminatory ability between tumor and normal samples and/or measures of PCa progression based on their 5mC and expression status. This evidence concerns the gene MEIS2 and posterior cortical atrophy.