ETNK2 and neoplasm: However, multivariate logistic regression analyses indicated that probes in ETNK2 (cg20136584, Wald p value = 0.0014) and NRG1 (cg00614182, Wald p value = 0.049) were independent predictors of tumor versus normal status in the TCGA cohort, indicating that increased methylation of these genes may be particularly important in PCa (Table 6).