However, multivariate logistic regression analyses indicated that probes in ETNK2 (cg20136584, Wald p value = 0.0014) and NRG1 (cg00614182, Wald p value = 0.049) were independent predictors of tumor versus normal status in the TCGA cohort, indicating that increased methylation of these genes may be particularly important in PCa (Table 6). The gene discussed is NRG1; the disease is neoplasm.