Our findings are in accordance with recent studies which hypothesize that the toxic effect originates from the soluble tau (monomeric or oligomeric), promoting trans-neuronal tau propagation and disease progression, rather than the tau aggregates, as the presence of NFT in neurons cannot be the sole reason for neurodegeneration and cognitive decline [3, 8, 9, 50–55]. The gene discussed is MAPT; the disease is Mental deterioration.