In conclusion, it seems worthwhile to measure both markers in cases of suspected benign ovarian tumors: an increased value of the 2 markers being suggestive of an ovarian cancer As suggested in a recent study by Goff et al., thresholds of 70 and 140 pmol/l according to menopausal status and 35UI/ml for CA125 seems preferable [52]. Here, MUC16 is linked to ovarian benign neoplasm.