In addition, by pooling the data of four studies, we found an obvious difference of OS in RCC and LCC regarding the KRAS status, that is, LCC patients with KRAS mutation has a shorter OS than with KRAS wild type, while RCC patients with KRAS mutation has no significant different OS compared with patients with KRAS wild type. This evidence concerns the gene KRAS and leukoencephalopathy with calcifications and cysts.