In this study, KRAS status has no obvious difference in colon cancer or rectal cancer, but showed significant difference in RCC and LCC, which was in consistent with Natsume et al. [11] and Tong et al. [27] reports, but in contrast to Cushman-Vokoun et al. [10] report. The gene discussed is KRAS; the disease is leukoencephalopathy with calcifications and cysts.