All the patients were referred to surgery, and three cases with advanced stage neoplasia were also treated with chemotherapy, using 5-fluorouracil / leukovorin / oxaliplatin (FOLFOX); this treatment was associated with the humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody, bevacizumab, in one case. The gene discussed is VEGFA; the disease is neoplasm.